6-(TERT-BUTOXYCARBONYL)-6-AZASPIRO[3.4]OCTANE-8-CARBOXYLIC ACID - Names and Identifiers
6-(TERT-BUTOXYCARBONYL)-6-AZASPIRO[3.4]OCTANE-8-CARBOXYLIC ACID - Physico-chemical Properties
6-(TERT-BUTOXYCARBONYL)-6-AZASPIRO[3.4]OCTANE-8-CARBOXYLIC ACID - Introduction
6-(TERT-BUTOXYCARBONYL)-6-AZASPIRO[3.4]OCTANE-8-CARBOXYLIC ACID is an organic compound with the chemical formula C12H19NO5.
Nature:
-Appearance: Colorless to light yellow solid
-Melting Point: about 100-104 ℃
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and ether
Use:
-Chemical synthesis: It is a commonly used protecting group, which is often used to protect unstable compounds such as carboxylic acid groups, amine groups and alcohol groups in organic synthesis.
-Drug research: commonly used in drug synthesis, intermediate synthesis and biological activity evaluation.
Method:
6-(TERT-BUTOXYCARBONYL)-6-AZASPIRO[3.4] There are many preparation methods for OCTANE-8-CARBOXYLIC ACID. The following is a common method:
1. First, N-benzyl -1,1-dimethyl urea and sodium sulfate are reacted in dimethyl sulfoxide to obtain N-benzyl -1-methyl urea.
2. Then, in the presence of thionyl chloride, it reacts with tert-butanol to produce N-benzyl -1-(tert-butoxy)-1-methyl urea.
3. Finally, the target product is obtained by treating with hydrofluoric acid under the catalysis of alkali.
Safety Information:
-The compound needs to be handled under laboratory conditions, taking care to avoid contact with skin and eyes.
-During use, good ventilation measures should be taken, and appropriate protective gloves and eye protection should be worn.
-This compound may be a potential risk to the environment and waste should be handled and disposed of properly.
Please note that the above information is for informational purposes only and specific properties, uses, manufacturing and safety information may need to be determined and supplemented based on specific experimental conditions and operational requirements. During the experiment, be sure to comply with the relevant chemical experiment safety regulations.
Last Update：2024-04-09 21:01:54